In the present article, scientific approach based on the Requirements of the time is mentioned, where modern interpretation based on various period is done. In terms of the historical events among the Muslims In format of five period of the descent, translation, interpretation, progression, interpretive studies, renaissance, contemporary, as well as damages and the challenges of this approach is considered. Then two scientific approach to research, that is, radical and extremist damage is studied. The result is that, in facing scientific approach, commentators and Quran studies have three positions: Extraction of all the sciences of the Qur'an, the correspondence sciences with the Qur'an; the implementation sciences for a better understanding of the Quran.